2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13683S2
    Mifepristone-d6
    		Antagonist
    Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
    Mifepristone-d<sub>6</sub>
  • HY-B0084S
    Dienogest-d4
    		Agonist
    Dienogest-d4 is deuterium labeled Dienogest.
    Dienogest-d<sub>4</sub>
  • HY-125547
    EIDD-1723
    EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649). EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR)-dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI).
    EIDD-1723
  • HY-106389
    Onapristone
    		Antagonist
    Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity.
    Onapristone
  • HY-W746582
    Norethindrone-d7
    Norethindrone-d7 (Norethisterone-d7) is the deuterium labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone-d<sub>7</sub>
  • HY-105634
    Nomegestrol
    		Agonist
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
    Nomegestrol
  • HY-B1095R
    Chlormadinone acetate (Standard)
    		Agonist
    Chlormadinone acetate (Standard) is the analytical standard of Chlormadinone acetate. This product is intended for research and analytical applications. 0
    Chlormadinone acetate (Standard)
  • HY-B0084S1
    Dienogest-d5
    		Agonist
    Dienogest-d5 is deuterium labeled Dienogest.
    Dienogest-d<sub>5</sub>
  • HY-119482
    Cymipristone
    		Antagonist
    Cymipristone (ZXH-951), a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
    Cymipristone
  • HY-B0648S1
    Medroxyprogesterone-d7
    		Agonist
    Medroxyprogesterone-d7 is deuterium labeled Medroxyprogesterone.
    Medroxyprogesterone-d<sub>7</sub>
  • HY-B0257AS
    Dydrogesterone-d6
    		Agonist
    Dydrogesterone-d6 is the deuterium labeled Dydrogesterone. Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency.
    Dydrogesterone-d<sub>6</sub>
  • HY-13676S1
    Megestrol acetate-d3-1
    		Inhibitor
    Megestrol acetate-d3-1 is deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
    Megestrol acetate-d<sub>3</sub>-1
  • HY-B0521S
    Altrenogest-d5
    		Agonist
    Altrenogest-d5 is the deuterium labeled Altrenogest. Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.
    Altrenogest-d<sub>5</sub>
  • HY-W753897
    Gestodene-d7
    Gestodene-d7 is the deuterium labeled Gestodene (HY-B0110). Gestodene is a progestin-based contraceptive. Gestodene is a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an azide group.
    Gestodene-d<sub>7</sub>
  • HY-106297
    Tosagestin
    Tosagestin(Org 30659) is a 19-nortestosterone–derived progestagen. Tosagestinsuppresses ovarian function to a level sufficient to inhibit ovulation. Tosagestininhibits cell growth in T47D-S cells.
    Tosagestin
  • HY-121677
    Norgestomet
    		Agonist
    Norgestomet is a compound with progesterone receptor agonist activity. The synthetic product has high purity and agonist activity on the progesterone receptor, while its 17β-isomer is inactive.
    Norgestomet
  • HY-B1095S2
    Chlormadinone acetate-d3
    		Agonist
    Chlormadinone acetate-d3 is the deuterium labeled Chlormadinone acetate. Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
    Chlormadinone acetate-d<sub>3</sub>
  • HY-B0891S1
    17α-Hydroxyprogesterone-13C3
    		Agonist 98.9%
    17α-Hydroxyprogesterone-13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
    17α-Hydroxyprogesterone-<sup>13</sup>C<sub>3</sub>
  • HY-B0110S
    Gestodene-d6
    		Agonist
    Gestodene-d6is the deuterium labeled Gestodene. Gestodene(SHB 331) is a progestogen hormonal contraceptive. Gestodene-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Gestodene-d<sub>6</sub>
  • HY-113889
    ZK112993
    		Antagonist
    ZK112993 is a potent progesterone receptor (PR) antagonist. ZK112993 significantly inhibits the growth of T61 human tumors in nude mice.
    ZK112993
Cat. No. Product Name / Synonyms Application Reactivity